1. γ fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.
- Author
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Sadhanandhan, Bindhya, Arun, Sreepriya, Long, Rebecca, Johnson, Alicia, Noll, Jamie, Ramchand, C, Olynyk, John, Farrell, David, and Kornblith, Lucy
- Subjects
Biomarkers ,COVID-19 ,Disease progression ,Fibrinogen ,Respiratory distress syndrome ,Humans ,COVID-19 ,Fibrinogen ,Biomarkers ,C-Reactive Protein ,Patient Acuity ,Retrospective Studies - Abstract
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO2). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95 % CI 64.8-74.8) mg/dL compared with 36.9 (95 % CI 31.4-42.4) mg/dL, p 93 %, GPF 62.5 (95 % CI 55.0-70.0) mg/dL, p = 0.01, AUC of 0.68, 95 % CI 0.57-0.78; Youdens index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.
- Published
- 2023